P2.2.10 Development of Guided SH-SAW based Wireless Sensing Platform for Monitoring Protein Binding

Event

14th International Meeting on Chemical Sensors - IMCS 2012
2012-05-20 - 2012-05-23
Nürnberg/Nuremberg, Germany

Chapter

P2.2 Resonant Sensors

Author(s)

C. Cheng, C. Feng, M. Atashbar - Western Michigan University (USA), K. Kalantar-Zadeh - RMIT University (Australia)

Pages

1433 - 1436

DOI

10.5162/IMCS2012/P2.2.10

ISBN

978-3-9813484-2-2

Price

free

Abstract

In this study, a wireless biosensing platform was developed for the detection of protein binding. The system consists of a layered ZnO/36° YX-LiTaO3 SH-SAW device and a microfluidic flow cell. The influence of the interactions between protein A and mouse IgG on the characteristics of the SH-SAW device was measured and analyzed for varying concentrations of mouse IgG. The experimental results demonstrated that the insertion loss of the device increased from -46.8 dB to -50.9 dB and the center frequency of the device decreased from 94.56 MHz to 94.49 MHz as the mouse IgG concentration was increased from 1 µM to 40 µM, respectively. This sensor platform enabled real time monitoring of protein binding within a microfluidic flow cell.