P1.5.5 Study of TiO2 NWs-based FET immunosensor: effect of surface immobilization methods
- Event
- 14th International Meeting on Chemical Sensors - IMCS 2012
2012-05-20 - 2012-05-23
Nürnberg/Nuremberg, Germany - Chapter
- P1.5 FET-based Sensors
- Author(s)
- C. Lin - Dept. Chem & Matls Eng., Tunghai University (Taiwan), Y. Chu, H. Chang - Inst. Biomed. Eng., National Cheng Kung University (Taiwan)
- Pages
- 1038 - 1041
- DOI
- 10.5162/IMCS2012/P1.5.5
- ISBN
- 978-3-9813484-2-2
- Price
- free
Abstract
Immobilization of biomolecule on biosensor surface is an important issue for develop higher sensitivity immunosensors. Recognition elements can be modified on material surface through chemical conjugate, physical adsorption and, polymer entrapment etc. Although most of these methods are well established, none of them can perform both in situ immobilization of biomolecues and be easily established. In this study, anti-rabbit IgG (1oAb) is encapsulated by a cyclic-voltammetry for electropolymerization of pyrrole propylic acid (Pa) on self-designed TiO2 NWs field effect transistor. A better specificity, selectivity and sensitivity can be achieved at nano-gram level (R2=0.903) when compared with 3-aminopropyltrimethoxysilane (APTMS).