C5.2 - Miniaturized drug delivery system TUDOS with accurate metering of microliter volumes
- Event
- AMA Conferences 2013
2013-05-14 - 2013-05-16
Nürnberg - Band
- Proceedings SENSOR 2013
- Chapter
- C5 - Measurement Systems
- Author(s)
- M. Richter, M. Wackerle, S. Kibler - Fraunhofer Institution for Modular Solid State Technologies EMFT (Germany), M. Biehl, T. Koch, C. Müller - Fraunhofer Institute for Biomedical Engineering IBMT (Germany), R. Halter - Fraunhofer Institute for Toxicology and Experimental Medicine ITEM (Germany), J. Nuffer - Fraunhofer Institute for Structural Durability and System Reliability LBF (Germany), O. Zeiter - Fraunhofer Institute for Reliability and Microintegration IZM (Germany)
- Pages
- 420 - 425
- DOI
- 10.5162/sensor2013/C5.2
- ISBN
- 978-3-9813484-3-9
- Price
- free
Abstract
A miniaturized drug delivery system for accurate dosing of drugs for therapy of cancer is presented. The weight of the system is less than 8 grams. Silicon micropumps with a stroke volume of 88 nl, and blocking pressure of 6 bar, drive the system. A novel and accurate flow monitoring principle based on capacitance measurement was developed and implemented into the drug delivery system. To prevent free flow, a self blocking safety valve was adapted to the drug micropump. Moreover, further safety features like catheter blockage detection, pump failure detection, bubble detection and a bubble separator was realized. System control and driver electronics to supply the pumps with high voltage was realized on a tiny flex PCB and integrated. System tests showed, that test dosing volumes of 12 μl can be delivered reliably with accuracy better than 4 %. The system is now ready for animal trial (rat model) for a new cancer therapy approach.