D9.2 - Impedance Measurement of Wound Infection Status
- Event
- AMA Conferences 2013
2013-05-14 - 2013-05-16
Nürnberg - Band
- Proceedings SENSOR 2013
- Chapter
- D9 - Medical Sensors
- Author(s)
- A. Schröter, G. Gerlach - Technische Universität Dresden (Germany), A. Rösen-Wolff - University Hospital Carl Gustav Carus, Dresden (Germany)
- Pages
- 628 - 632
- DOI
- 10.5162/sensor2013/D9.2
- ISBN
- 978-3-9813484-3-9
- Price
- free
Abstract
Wound infection monitoring is a matter of high interest in wound treatment. Therefore, we extracted sensor parameters suitable to identify massive pathogen presence. One method is to measure neutrophil-derived extracellular DNA as an immediate response of the immune system. We proofed that impedance measurement is a reasonable measurement technique for this parameter. Our sensor concept comprises a plenary or fiber-based setup which could be integrated into a wound cover. Proof-of-principle experiments using impedance spectroscopy in cell cultures showed a dependency between extracellular DNA formation and impedance rise. This was verified by microscopic observation of fluorescently stained samples. A reproducible impedance signal deviation of in average 34% after lately 4 hours was observed.