P2EM.5 - Gold-coated Black Silicon: An Efficient Substrate for Laser Desorption Ionization Mass Spectrometry Applications
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- P-2 - Emerging Sensor Technologies
- Author(s)
- S. Iakab, P. Rafols, X. Correig - Rovira i Virgili University, Department of Electronic Engineering, Tarragona (Spain)
- Pages
- 755 - 756
- DOI
- 10.5162/IMCS2018/P2EM.5
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
Mass spectrometry imaging is a label-free analytical technique capable of molecularly characterizing biological samples, including tissues and cell lines. The organic matrices used in matrix-assisted laser desorption/ionization mass spectrometry experiments are not suitable for low weight compounds (i.e. metabolites) due to the big ions interference generated by the organic matrix. The use of solid-state substrates instead of the classical matrices is very appropriate to overcome this problem. In this study we focus on developing a novel nanostructured substrate based on black silicon fabricated by reactive ion etching and coated with sputtered gold. The hydrophobic/hydrophilic properties of this surface have been tailored in order to detect both polar and nonpolar compounds. This surface demonstrated to be very effective for analyzing imprinted mouse brain tissues and fingerprints.