PT5.203 - Solid support counts: towards development of all-solid state sensor for ketoprofen
- Event
- EUROSENSORS XXXVI
2024-09-01 - 2024-09-04
Debrecen (Hungary) - Band
- Poster
- Chapter
- PT5 - Chemical Sensors
- Author(s)
- L. Lvova, P. Di Menna, R. Paolesse - University of Tor Vergata, Rome (Italy), G. M. Romano, A. Bencini - University of Florence, Sesto Fiorentino (Italy)
- Pages
- 391 - 392
- DOI
- 10.5162/EUROSENSORSXXXVI/PT5.203
- ISBN
- 978-3-910600-03-4
- Price
- free
Abstract
The properties of all-solid-state optical sensors based on the polyamine receptors PP-1 and PP-2 bearing pyrene fluorogenic groups able to signal selective ketoprofen, KP, binding through the en-hancement of the fluorescence emission have been investigated. The series of PVC polymeric mem-branes, plasticized with different plasticizers and doped with fully protonated PP-2 ligand, together with TDACl or TDMACl anion exchanger in 1:1, 1:2 and 1:3eq. ratio was studied in order to tune the highest selectivity toward KP. The appropriate choice of a solid support, selecting from cellulose-based or glass materials, influences significantly the performance of sensor. The fluorescent intensity of developed optical sensors increased with KP concentration growth. The images of sensors were acquired with smartphone and digitalized with a free on-line software of image processing in order to construct calibration model. Developed chemical sensors have shown the possibility to detect KP in the concentration range 2 μM – 0.1mM, with low influence of several interfering ions of the similar structure, such as naproxen, ibuprofen and benzoate. All-solid state sensor on paper support was successfully applied for KP assessment in pharmaceutical composition OkiTask with RSD of 2.1% and recoveries in range 98-102%.