P5.15 - Simulation, Manufacturing and Evaluation of Injection Molded Microbioreactors
- Event
- AMA Conferences 2017
2017-05-30 - 2017-06-01
Nürnberg, Germany - Band
- Proceedings Sensor 2017
- Chapter
- P5 - Gas, Chemo and Biosensors
- Author(s)
- F. Schütze, N. Matuschek, S. Zinn, A. Böhme, A. Foitzik - University of Applied Sciences Wildau (Germany), L. Santo - University of Rome Tor Vergata (Italy)
- Pages
- 738 - 743
- DOI
- 10.5162/sensor2017/P5.15
- ISBN
- 978-3-9816876-4-4
- Price
- free
Abstract
Miniaturized flow through devices offer the possibility to mimic the in vivo microenvironment for cultivated cells. In order to guaranty sterility and to eliminate the risk of cross contamination, bioreactors are commonly designed as disposable systems. In order to produce them in large numbers and at low cost, an injection molding process is necessary. Prior to the actual micro injection a simulation software is used to determine the optimal parameter for the injection molding process and machine settings. Hereby, different combinations of processing parameters can be simulated by using a test matrix. Subsequently the optimal setting is used to fabricate the bioreactor. The results are evaluated by comparing the punctual deviations of the actual surface value from the nominal surface value of the CAD-Model.