P2BM.5 - Synthesis of a Novel MIP Thin Layer and Monodisperse MIP- Nanoparticles for Detection of Creatinine
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- P-2 - Biomimetic Sensors
- Author(s)
- S. Haghdoust, P. Lieberzeit - University of Vienna, Department of Physical Chemistry, Vienna (Austria)
- Pages
- 694 - 695
- DOI
- 10.5162/IMCS2018/P2BM.5
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
Herein we report molecularly imprinted polymers (MIP) to design a novel biomimetic assay for the detection of creatinine, which is evaluation bioindicator of renal function and muscle damage. Creatinine MIPs both as thin films and nanoparticles (NPs) were synthesized by precipitation polymerization and characterized with quartz crystal microbalance (QCM) and dynamic light scattering (DLS). Selectivity was verified against creatine. The experimental results show the limit of detection nearly 41 ppm for MIP NPs and 121 ppm for MIP thin film. Selectivity factor recorded four-time higher amount for MIP NPs in comparison with MIP thin film.