A1.4 - Impedance Spectroscopy for Biological Applications

Event

SENSOR+TEST Conferences 2011
2011-06-07 - 2011-06-09
Nürnberg

Band

Proceedings SENSOR 2011

Chapter

A1 - Impedance Spectroscopy

Author(s)

G. Dame, G. Urban, F. Spies - Albert-Ludwigs-Universität Freiburg (Germany)

Pages

46 - 46

DOI

10.5162/sensor11/a1.4

ISBN

978-3-9810993-9-3

Price

free

Abstract

Many physiological parameters and phenomena affected impedance measurements. The lack of specificity could be a drawback, but impedance measurements can be used in a simple and practical way. The systems are minimal invasive, providing a high sensitivity and the measurements can be taken in real-time, in spite of the fact that in several cases the origin of impedance changes is not fully understood.
For medical applications they are used as an auxiliary technique for monitoring therapy procedures and for monitoring cell or tissue cultures for tissue engineering, drug screening and microbial cell culturing. A micro system will be presented for monitoring the biomass of microbial cultures.
State of the art methods for determining the inhibiting effect of toxic components are cumbersome, because parallelization is barely feasible. Standard bacterial tests like growth inhibition tests measure cell numbers by optical density or plating. With such time-consuming methods only endpoint detection is possible and measuring of colored and high turbidly liquids are not possible. With our research we aim to overcome the mentioned problems.