PT6.198 - Development of a Novel Self-Immolative System Activated by DT-diaphorase for Hypoxic Environments
- Event
- EUROSENSORS XXXVI
2024-09-01 - 2024-09-04
Debrecen (Hungary) - Band
- Poster
- Chapter
- PT6 - Biochemical sensors, Microfluidics, Lab-on-a-Chip and Organ-On-Chip Systems
- Author(s)
- P. Rodrigo, J. A. Sáez, M. Barros, P. Arroyo, P. Gaviña - Universitat de València, Valéncia (Spain)
- Pages
- 457 - 458
- DOI
- 10.5162/EUROSENSORSXXXVI/PT6.198
- ISBN
- 978-3-910600-03-4
- Price
- free
Abstract
In this work, a total synthesis of a self-immolative material has been done. Firstly, MCM-41 nanoparticles were synthesized, after that, they were loaded with a fluorophore, and finally the pores were capped with an azo-based molecule. The aim of this work is to detect hypoxic environments based on the over-expression of DT-diaphorase, leading to the breakdown of the azo bond and the releasing of the fluor-ophore.